Alnylam Reports P-II Study (KARDIA-1) Results of Zilebesiran for Hypertension in Patients at High Cardiovascular Risk
Shots:
- The P-II study evaluates zilebesiran (RNAi therapeutic targeting liver-expressed AGT) as monotx. vs PBO in 394 adults. The trial met its 1EPs & showed a dose-dependent, clinical reduction in 24hr. mean systolic blood pressure (SBP) at 3mos. with PBO-subtracted reduction ≥15mmHg with 300 & 600mg doses
- The study also met 2EPs incl. significant change in 24hr. mean SBP at 6mos., change in office SBP at 3 & 6mos. Zilebesiran was associated with dose-dependent, potent, and durable knockdown of serum AGT levels through 6mos. & demonstrated an encouraging safety & tolerability profile, SAEs (3.6% vs 6.7%)
- The P-II (KARDIA-2) study results of zilebesiran in combination with one of three standard classes of anti-hypertensive medications are expected in early 2024
Ref: Businesswire | Image: Alnylam
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